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Taylormade M4 driver setting | Golf Monthly
If you are going for the trial and error approach then start std and keep increasing the loft a little at a time until you no longer see improvements.
Then go back and add fade bias in the same way (if you really have to.
Or go and see a pro with a trackman and sort it once and for all in no time flat...there are tweaks beyond tweaks with all the available adjustments.